Who first discovered this disorder? Where, when and under what circumstances was it discovered?

It was discovered by a guy named alexander in 1914.
Image result for alexander disease
Image result for alexander disease

What are the symptoms/characteristics associated with this disorder? At what age do the symptoms begin? Are the symptoms treatable? If so, how? Is the disorder fatal?

It is usually fatal. It can prevent gaining mass and is usually seen in children around two, but also later on in life. It can also impair/slow the growth of physical, mental, and behavioral skills when compared to usual kids. Also they can have seizures. There isn’t really anything that can be done to treat it.
What is the inheritance pattern of the disorder: dominant, recessive, sex-linked, autosomal, other?

It is a dominant mutation. There is neither a greater chance of developing the disease from the baby by being or coming from a female or male.
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Are there any environmental factors that can affect the symptoms?

There seems to be no environmental effects that cause the disease
How common is the disorder? Does it occur more frequently in certain parts of the world or in certain ethnic groups or in one sex?

It is a rare disease seen in only about 500 people since the discovery of it. There isn’t really a greater or lesser chance of having the disease from different sexes, ethnic group, or region of the world. Everyone has the same 1:1,000,000 ratio of containing the disease.
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What tests are done to confirm a diagnosis of this disorder?

There is some DNA analysts tests be done to identify the disease. Also, an MRI scan can also be used to help see patterns associated with alexander disease.
Which chromosome(s) is responsible for this disorder? Is it caused by a gene mutation? Which gene is involved? Is it caused by a chromosomal mutation? Which type: nondisjunction, deletion, inversion?

The disease is caused by a genetic mutation for structural protein which is called glial fibrillary acidic protein (GFAP). However, that is only the cause for 95% of the disease, there is a 5% of patients for which the cause is unknown.

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