1.Crohn’s Disease was named after Dr. Burrill B. Crohn, who first described the disease in 1932 along with his colleagues Dr. Leon Ginzburg and Dr. Gordon D. Oppenheimer. Dr. Crohn lived in New York City.
external image uo6w1Afaid0Syl491-mmuhE_4ji5Ouda5IEEhe1W1WV06l29WywNO9AdDNKqt-RjT6fmwxFs3zk1rQ2-MhPIa2GBw6kdbOHV0d1prG1W_GMKkZ2ObGRe-EN89sJEVRaPlDCiag7e
external image WNBP27hEyWDcjaW-iMrpoG3G1tje1qFmtYnknE0SrQdkQlt0BYAOQ4KBS-B7tfIADWFfU1a2p8lEtQlfpbk1hhHGsD6Dck_gdUNnNrJIXtkn5gtf68kZMpNeD7AjOYuOVal0b8g1
2. Crohn’s Disease is a chronic inflammatory disease of the intestines. Crohn's disease can appear at any age, but it is most often diagnosed in people between 13 and 30 years of age. Symptoms include…
  • Persistent Diarrhea
  • Rectal bleeding
  • Urgent need to move bowels
  • Abdominal cramps and pain
  • Sensation of incomplete evacuation
  • Constipation (can lead to bowel obstruction)
  • Fever
  • Loss of appetite
  • Weight Loss
  • Fatigue
  • Night sweats
  • Loss of normal menstrual cycle
Crohn's disease cannot be completely cured; however, treatment consists of anti-inflammatory medications, surgery (bowel resection), and self-care. Only very rarely will a patient die from complications of Crohn's disease.
3. Crohn's disease is a major recessive gene, with a high penetrance. The inheritance pattern of Crohn disease is unclear because many genetic and environmental factors are likely to be involved. However, Crohn’s disease tends to be passed down in families; about 15 percent of affected people have a first-degree relative with the disorder.
external image B8TkpNAr4LjKkOA-6yK9Qd5oKtiYFykn-yLIK--I5TJE21Gvv7BXTw6oM0ojBRzld1hVYfIL1eDyR4rUICreC7QVVdC4-l697bx_NElF8y2rJ2XGeXc9c9RGyd58Mn484aPclmdc
external image qZJNdKD82C3w4fGFnLbGimaDbmNrMmSEBDuOlnWurx2dSYXulsnuT8c4FpjoU-Hz80ftkwy7nB4ZLYCsQNe5OY_v9wfOUrOPhvSQYb0WvaHNkbq2bQCr54Npc3JGS3sYEOqWoB31
4. Smoking has been seen as both aggravate and alleviate. The relationship between smoking and Crohn’s Disease is not simple. Studies have shown that people who smoke are more likely to develop Crohn’s Disease. However, different researchers have found that smoking appears to decrease the severity the disease, although it still carries many other health risks (such as lung cancer). In addition, other research has suggested that smoking has increased the severity of the disease. In addition some factors that tend to bring out the symptoms of the disease are:
  • Cigarette smoke
  • Stress
  • Foods high in fat and fiber
  • Alcohol
  • Milk protein
5. About 780,000 Americans have Crohn’s disease. Researchers have estimated that 6 to 15 new cases of Crohn’s disease are diagnosed per 100,000 people each year. It has been researched on whether or not Crohn’s disease occurs more frequently in certain parts of the world or in certain ethnic groups but the findings have not been definite. Population-based studies show that Crohn’s disease is slightly more common in women than men.
external image --YdEVVPrxnWzFaJRKN8qElLRo5w9LeQCIESal2zJOKj9O85B64FaQnWvB8VzEAyYMHfOvRaH7863iTLi6o7L-mDyVHhWV8y0-C5pt_8guH1bNcnmAtxH6nqkHE6qUBqr_y-3d6Wexternal image 2mzVfOpxoKZcyxPdgmMAGUqzMZdQrN52oBQt1aMJGpMQBaXUSuhrkjuMK47I6DL2EMNqWTJQFYvYrC-9coR-sfl-T3cni16s6ShkzOSfuZqp7Z1E-lNvuXMEAiCyG6z_UBOXSD45
external image xm8TcCQS8f4yk8zRpK4c3IUY4_asmgj4TTBaicSpr4gGKHZxcTK6xWQJJZFoDUwko57jzCcwy1FonPZHSxkbIkXijB3JUT1_0Nq8EkMJsB3bJiqnjDCGlTtr_hpD_kyVZ6QexKex
This image is the result of a Leukocyte Scintigraphy.
6. The possible tests that are done to confirm Crohn’s Disease are…
  • X-Rays
  • Computerized Tomography (CT)
  • Leukocyte Scintigraphy (white blood cell scan)
  • Endoscopy
  • Endoscopic Ultrasound (EUS)
  • Antibody Blood Tests (Biomarkers)

In addition, every person diagnosed with this disease has routine blood tests.
7. Experts have found links between the disease and mutations in genes located on chromosomes 5 and 10. Furthermore, mutations in the ATG16L1, IL23R, IRGM, and NOD2 genes appear to increase the risk of developing Crohn’s disease.
external image qnn7qS1bDxZqxmEug2RQprzhXMPan3jp08RePf2d90CPwxrKNUm42EK19f5OrZaxymwt2E4ily2XUIfCOCwaY-b6f_CyshibzseuNSYpp8sLETiPh3dKHU97Q6VvQsJnKLL5NhgW
external image qBAnevoMUCciuLnCQmh8wCLaYeFKPPc8g3y18AQH5q0eY5qcotQvQPug9JIPL_7p6MlJjVtl8bPO7LqbnPEV4jPDRr0PqwfB8X1J6m8et1lMggDaAl3w1YhWOnwV_jgIrHM446ol
Works cited