Alexander+disease


 * **Who first discovered this disorder? Where, when and under what circumstances was it discovered? **

It was discovered by a guy named alexander in 1914. ||  || **What are the symptoms/characteristics associated with this disorder? At what age do the symptoms begin? Are the symptoms treatable? If so, how? Is the disorder fatal? **

It is usually fatal. It can prevent gaining mass and is usually seen in children around two, but also later on in life. It can also impair/slow the growth of physical, mental, and behavioral skills when compared to usual kids. Also they can have seizures. There isn’t really anything that can be done to treat it. ||
 * **What is the inheritance pattern of the disorder: dominant, recessive, sex-linked, autosomal, other? **

It is a dominant mutation. There is neither a greater chance of developing the disease from the baby by being or coming from a female or male. ||  || **Are there any environmental factors that can affect the symptoms? **

There seems to be no environmental effects that cause the disease ||
 * **How common is the disorder? Does it occur more frequently in certain parts of the world or in certain ethnic groups or in one sex? **

It is a rare disease seen in only about 500 people since the discovery of it. There isn’t really a greater or lesser chance of having the disease from different sexes, ethnic group, or region of the world. Everyone has the same 1:1,000,000 ratio of containing the disease. ||

 || **What tests are done to confirm a diagnosis of this disorder? **

There is some DNA analysts tests be done to identify the disease. Also, an MRI scan can also be used to help see patterns associated with alexander disease. ||
 * **Which chromosome(s) is responsible for this disorder? Is it caused by a gene mutation? Which gene is involved? Is it caused by a chromosomal mutation? Which type: nondisjunction, deletion, inversion? **

<span style="font-family: Arial,Helvetica,sans-serif;">The disease is caused by a genetic mutation for structural protein which is called glial fibrillary acidic protein (GFAP). However, that is only the cause for 95% of the disease, there is a 5% of patients for which the cause is unknown. || || **<span style="font-family: Arial,Helvetica,sans-serif;"> Work Cited: **
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