Edward's+syndrome

EDWARDS SYNDROME John Edwards discovered this disease in 1960. Edwards syndrome is also called Trisomy 18. There are two names for it and either work to call it. It was discovered back in the day when John Edwards first described the disease as Trisomy. He reported 20 plus cases of cornelia de Lange syndrome, a rare genetic disease. He was born in London before discovering the disease in Britain from finding a person with the condition, then later doing further research.
 * 1) Who first discovered this disorder? Where, when and under what circumstances was it discovered?

What are the symptoms/characteristics associated with this disorder? At what age do the symptoms begin? Are the symptoms treatable? If so, how? Is the disorder fatal? The symptoms of Edwards syndrome are All symptoms begin either as soon as the baby is born or a few months into the baby’s life. Kids with Edwards Syndrome who survived the first 30 days, only 36% live to one year. This disease is not treatable and does not so far have a cure. It is very rare for a child to survive Edwards syndrome. Many infants die within the first month. Those few who survive may have poor eating, digesting problems, delayed growth, and many other complicated problems, including mental problems. There are not any ways to prevent this it is an extra chromosome 18 in the body, which cannot be cured. The body is only meant to have 1, so when 2 more gets involved it affects all the organs, body function, and development. It is also found during ultrasounds before birth.
 * a low birth weight
 * a small jaw and mouth
 * an abnormally shaped, small head
 * overlapping fingers and clenched fists [[image:https://lh6.googleusercontent.com/3HBj1kVgzuHITaUwdjzR8iMHxex9LD9iP1jziG92gaIo3tIGq7XFrw7_VHTx4Ckf8qKJgzNEXEW0HGT8jwXKZYRpDX4sTQG9O36Xcb1PHDWExFAsQbdmQ8n2UsrTkhQKdgBCJH3f width="315" height="256" align="right"]]
 * “rocker-bottom” feet, low-set ears;
 * defects in the heart and other organs

What is the inheritance pattern of the disorder: dominant, recessive, sex-linked, autosomal, other? Edwards syndrome is autosomal dominant. There are many ways different types, but the main one is autosomal dominant. The is caused by the extra chromosome on the chromosome 18. Its only meant to have two, but when another joins it hurts the baby. Edwards syndrome is a genetic anomaly that comes during the production of sperm and egg cells in either meiosis 1, or meiosis 2. In meiosis 1 diploid cells divide have 2 copies of chromosome, which go into two making two daughter cells. In meiosis 2 the 2 daughter cells divided into 4 haploid cells.

<span style="color: #ff00ff; font-family: &#39;Times New Roman&#39;; font-size: 14pt; vertical-align: baseline;">Are there any environmental factors that can affect the symptoms (either aggravate or alleviate)? <span style="font-family: &#39;Times New Roman&#39;; font-size: 11pt; vertical-align: baseline;">Edwards syndrome does not have an affect either aggravate or alleviate. Since the disease is from genetics and chromosomes, there outside world does not have an effect. As well the child with the disease mostly dies before the first month, they don't spend much time outside the hospital. There is no bad outcome from outside world as well.

<span style="color: #ff00ff; font-family: &#39;Times New Roman&#39;; font-size: 14pt; vertical-align: baseline;">How common is the disorder? Does it occur more frequently in certain parts of the world or in certain ethnic groups or in one sex? Edwards syndrome is not very common. 1 in 5,00 babies are born with this disease in the United States. Girls are way more common to get this disease. The older the woman gets, the more highly the disease is common for her baby. It is more common throughout the pregnancy, most do not last throughout the whole pregnancy. It does not change throughout the country. Where you are the chances are the same, since the genetic disorder is from chromosomes and DNA.

<span style="color: #ff00ff; font-family: &#39;Times New Roman&#39;; font-size: 14pt; vertical-align: baseline;">What tests are done to confirm a diagnosis of this disorder? <span style="font-family: &#39;Times New Roman&#39;; font-size: 11pt; vertical-align: baseline;">To figure out this disease they first start by finding it in the ultrasound. When they find that over time they do more tests to find out how advanced the disease is. Some cases are worse than others, and some are too far gone to have anything be done. In cases were its not as far, they try to do as much as they can. Yet nothing is able to stop in today's world.

<span style="color: #ff00ff; font-family: &#39;Times New Roman&#39;; font-size: 14pt; vertical-align: baseline;">Which chromosome(s) is responsible for this disorder? Is it caused by a gene mutation? Which gene is involved? Is it caused by a chromosomal mutation? Which type: nondisjunction, deletion, inversion, etc.? <span style="font-family: &#39;Times New Roman&#39;; font-size: 11pt; vertical-align: baseline;">In Edwards disease chromosome 18 is responsible for this disorder. It is caused by gene mutation, when a chromosome replicates too many times. Its a form of chromosomal mutation. It is not inversion, nor nondisjunction, or deletion, but it is duplication. That is when a section of DNA is duplicated and both end on the same chromosome. It can happen during the process of meiosis when an error occurs.


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